Abstract
This study investigated the efficacy of isotonic bioflavonoid supplementation, OPC-3 on 61 individuals presenting with risk factors meeting the criteria for metabolic syndrome. Subjects were supplemented with a proprietary isotonic bioflavonoid OPC-3 or placebo over 2 months. Plasma oxidative stress status was significantly lowered by 10.1% with OPC-3. All major cardiovascular risk factors were improved with blood pressure, total cholesterol, and fasting blood glucose lowered. OPC-3 significantly improved endothelial function as evaluated by increased vasorelaxation in reactive hyperemia and enhanced diastolic carotid artery flow. Cardiac ultrasound scanning revealed a significant increase of left ventricular ejection fraction. Skin microcirculation was enhanced, and better tissue perfusion led to significantly increased transcutaneous oxygen partial pressure and decreased pCO(2). With OPC-3 a dramatic and significant plasma C-reactive protein decrease by 52.1% occurred. Individuals may improve key cardiovascular risk factors by daily supplementation with the bioflavonoid OPC-3 as an important part of a healthier lifestyle.
Publication types
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Randomized Controlled Trial
MeSH terms
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Biomarkers / blood
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Blood Pressure / drug effects
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Cardiovascular Agents / adverse effects
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Cardiovascular Agents / therapeutic use*
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Cardiovascular Diseases / etiology
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Cardiovascular Diseases / metabolism
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Cardiovascular Diseases / physiopathology
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Cardiovascular Diseases / prevention & control*
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Carotid Arteries / drug effects
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Carotid Arteries / physiopathology
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Dietary Supplements*
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Double-Blind Method
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Female
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Flavonoids / adverse effects
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Flavonoids / therapeutic use*
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Forearm / blood supply
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Hemodynamics / drug effects*
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Humans
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Male
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Metabolic Syndrome / complications
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Metabolic Syndrome / drug therapy*
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Metabolic Syndrome / metabolism
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Metabolic Syndrome / physiopathology
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Microcirculation / drug effects
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Microcirculation / physiopathology
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Middle Aged
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Oxidative Stress / drug effects
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Plant Extracts / therapeutic use*
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Regional Blood Flow / drug effects
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Risk Factors
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Skin / blood supply
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Stroke Volume / drug effects
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Treatment Outcome
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Ultrasonography, Doppler, Duplex
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Vasodilation / drug effects
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Ventricular Function, Left / drug effects
Substances
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Biomarkers
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Cardiovascular Agents
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Flavonoids
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Plant Extracts