Cytotoxic principles of Securinega virosa: virosecurinine and viroallosecurinine and related derivatives

J Pharm Sci. 1991 Apr;80(4):325-7. doi: 10.1002/jps.2600800408.

Abstract

Virosecurinine (1) and viroallosecurinine (2) were isolated as two cytotoxic alkaloids from the leaves of Securinega virosa. A comparison of the cytotoxicity of 1 and several of its derivatives indicates that an alpha,beta- and a gamma,delta-unsaturated lactone located in a strained ring system, such as rings -B, -C, and -D of 1, is structurally required for significant cytotoxicity.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Animals
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Azepines*
  • Cell Survival / drug effects
  • Drug Screening Assays, Antitumor
  • Lactones*
  • Piperidines*
  • Plants, Medicinal / analysis*
  • Structure-Activity Relationship
  • Tumor Cells, Cultured / drug effects

Substances

  • Alkaloids
  • Antineoplastic Agents, Phytogenic
  • Azepines
  • Lactones
  • Piperidines
  • virosecurinine