Abstract
Virosecurinine (1) and viroallosecurinine (2) were isolated as two cytotoxic alkaloids from the leaves of Securinega virosa. A comparison of the cytotoxicity of 1 and several of its derivatives indicates that an alpha,beta- and a gamma,delta-unsaturated lactone located in a strained ring system, such as rings -B, -C, and -D of 1, is structurally required for significant cytotoxicity.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Animals
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Azepines*
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Cell Survival / drug effects
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Drug Screening Assays, Antitumor
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Lactones*
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Piperidines*
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Plants, Medicinal / analysis*
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Structure-Activity Relationship
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Tumor Cells, Cultured / drug effects
Substances
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Alkaloids
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Antineoplastic Agents, Phytogenic
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Azepines
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Lactones
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Piperidines
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virosecurinine