Plasma uric acid in patients receiving anticonvulsant monotherapy

H A Ring; A J Heller; W J Marshall; A L Johnson; E H Reynolds

doi:10.1016/0920-1211(91)90070-v

Plasma uric acid in patients receiving anticonvulsant monotherapy

Epilepsy Res. 1991 Apr;8(3):241-4. doi: 10.1016/0920-1211(91)90070-v.

Authors

H A Ring¹, A J Heller, W J Marshall, A L Johnson, E H Reynolds

Affiliation

¹ Department of Neurology, King's College Hospital, London, U.K.

PMID: 1868823
DOI: 10.1016/0920-1211(91)90070-v

Abstract

In newly diagnosed adult patients with epilepsy followed prospectively on monotherapy, carbamazepine and phenytoin were associated with a fall in plasma uric acid, but sodium valproate and phenobarbitone were associated with a rise in plasma uric acid. The mechanisms and significance of these findings are discussed.

MeSH terms

Adolescent
Adult
Anticonvulsants / therapeutic use*
Carbamazepine / therapeutic use
Epilepsy / blood*
Epilepsy / drug therapy
Humans
Phenobarbital / therapeutic use
Phenytoin / therapeutic use
Prospective Studies
Uric Acid / blood*
Valproic Acid / therapeutic use

Substances

Anticonvulsants
Uric Acid
Carbamazepine
Valproic Acid
Phenytoin
Phenobarbital