Abstract
Interactions between the renin-angiotensin-aldosterone system and other mechanisms determining sodium balance are important in the pathophysiology of hypertension. Low-renin hypertension is a common type of resistant hypertension and is often associated with increased sodium retention. The importance of investigation, factors determining renin and aldosterone levels, and drug therapies in low-renin hypertension are reviewed.
MeSH terms
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Aldosterone / blood
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Antihypertensive Agents / therapeutic use
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Blood Pressure* / drug effects
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Diuretics / therapeutic use
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Down-Regulation
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Drug Resistance
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Drug Therapy, Combination
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Humans
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Hypertension / drug therapy
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Hypertension / metabolism*
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Hypertension / physiopathology
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Kidney / drug effects
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Kidney / innervation
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Kidney / metabolism*
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Renin / blood*
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Renin-Angiotensin System* / drug effects
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Sodium / metabolism
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Sympathetic Nervous System / physiopathology
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Treatment Outcome
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Water-Electrolyte Balance
Substances
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Antihypertensive Agents
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Diuretics
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Aldosterone
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Sodium
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Renin