Detection of VM55599 and preparaherquamide from Aspergillus japonicus and Penicillium fellutanum: biosynthetic implications

J Nat Prod. 2008 Sep;71(9):1574-8. doi: 10.1021/np800292n. Epub 2008 Aug 28.

Abstract

The secondary metabolites VM55599 (4) and preparaherquamide (5) have been identified by LC-MS(n) analysis as natural metabolites in cultures of Penicillium fellutanum, whereas preparaherquamide has been identified only in cultures of Aspergillus japonicus. In accord with a previous proposal, the identification of both metabolites, which have a diastereomeric relationship, provides indirect support for a unified biosynthetic scheme.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aspergillus / chemistry*
  • Indolizines / chemistry
  • Indolizines / isolation & purification*
  • Molecular Structure
  • Penicillium / chemistry*
  • Spiro Compounds / chemistry
  • Spiro Compounds / isolation & purification*

Substances

  • Indolizines
  • Spiro Compounds
  • VM 55599
  • paraherquamide