There are many aspects of mast cell and basophil biology that are being explored today. Notably, there is a wide variety of studies of the roles these two cell types play in the development of a multitude of diseases and the role they play in the general immune response. But the original reasons for studying these two cells types--because they are considered crucial to immediate hypersensitivity reactions--remain a driving force for research. These two cell types express the complete high affinity IgE receptor and aggregation of this receptor results in the secretion of multiple potent mediators that cause many of the signs and symptoms of an allergic reaction. Understanding more about the biology of the receptor and the signaling that it initiates remains important to the development of new therapeutic approaches to inhibit this reaction.