Abstract
Recent studies have demonstrated that novel therapeutic combinations are challenging melphalan and prednisone (MP) as the standard of care in elderly patients with multiple myeloma. Combination regimens containing bortezomib or thalidomide can achieve response rates, especially complete response rates, which are superior to those seen with standard MP alone, and offer new possibilities for this patient population.
Publication types
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Clinical Trial, Phase III
MeSH terms
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Aged
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Antineoplastic Combined Chemotherapy Protocols / adverse effects
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Boronic Acids / administration & dosage
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Bortezomib
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Humans
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Melphalan / administration & dosage
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Multiple Myeloma / drug therapy*
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Prednisone / administration & dosage
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Pyrazines / administration & dosage
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Thalidomide / administration & dosage
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Treatment Outcome
Substances
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Boronic Acids
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Pyrazines
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Thalidomide
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Bortezomib
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Melphalan
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Prednisone