Update on recent developments for patients with newly diagnosed multiple myeloma

Ann N Y Acad Sci. 2008 Sep:1138:19-21. doi: 10.1196/annals.1414.004.

Abstract

Recent studies have demonstrated that novel therapeutic combinations are challenging melphalan and prednisone (MP) as the standard of care in elderly patients with multiple myeloma. Combination regimens containing bortezomib or thalidomide can achieve response rates, especially complete response rates, which are superior to those seen with standard MP alone, and offer new possibilities for this patient population.

Publication types

  • Clinical Trial, Phase III

MeSH terms

  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Boronic Acids / administration & dosage
  • Bortezomib
  • Humans
  • Melphalan / administration & dosage
  • Multiple Myeloma / drug therapy*
  • Prednisone / administration & dosage
  • Pyrazines / administration & dosage
  • Thalidomide / administration & dosage
  • Treatment Outcome

Substances

  • Boronic Acids
  • Pyrazines
  • Thalidomide
  • Bortezomib
  • Melphalan
  • Prednisone