Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP)

Genomics. 1991 Jul;10(3):640-5. doi: 10.1016/0888-7543(91)90446-l.

Abstract

We have established PCR assays for the genes coding for the major proteins of the desmosome type of cell junction, the desmosomal cadherins DGI (desmoglein) and DGII/III (desmocollins), and the plaque proteins DPI/II (desmoplakin) and DPIII (plakoglobin) and used them to test human-mouse and human-rat somatic cell hybrids with different contents of human chromosomes. From these data we were able to assign DGI to chromosome 18 (DSG), DGII/III to chromosome 9p (DSC), DPI/II to chromosome 6p21-ter(DSP), and DPIII to chromosome 7 (JUP).

MeSH terms

  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 18*
  • Chromosomes, Human, Pair 6*
  • Chromosomes, Human, Pair 7*
  • Chromosomes, Human, Pair 9*
  • Cytoskeletal Proteins / genetics*
  • Desmocollins
  • Desmogleins
  • Desmoplakins
  • Desmosomes*
  • Genes
  • Humans
  • Hybrid Cells
  • Mice
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Rats
  • gamma Catenin

Substances

  • Cytoskeletal Proteins
  • DSP protein, human
  • Desmocollins
  • Desmogleins
  • Desmoplakins
  • Dsp protein, mouse
  • gamma Catenin

Associated data

  • GENBANK/J05211
  • GENBANK/M23410
  • GENBANK/X56654
  • GENBANK/X56807