Bismacrocyclic inhibitors of hepatitis C NS3/4a protease

Angew Chem Int Ed Engl. 2008;47(47):9104-7. doi: 10.1002/anie.200803298.
No abstract available

MeSH terms

  • Antiviral Agents / chemical synthesis
  • Antiviral Agents / chemistry*
  • Antiviral Agents / pharmacology
  • Carbamates / chemistry
  • Carbamates / pharmacology
  • Carrier Proteins / antagonists & inhibitors*
  • Hepacivirus / drug effects
  • Hepacivirus / enzymology*
  • Intracellular Signaling Peptides and Proteins
  • Macrocyclic Compounds / chemical synthesis
  • Macrocyclic Compounds / chemistry*
  • Macrocyclic Compounds / pharmacology
  • Protease Inhibitors / chemical synthesis
  • Protease Inhibitors / chemistry*
  • Protease Inhibitors / pharmacology
  • Quinolines / chemical synthesis
  • Quinolines / chemistry*
  • Quinolines / pharmacology
  • Structure-Activity Relationship
  • Thiazoles / chemistry
  • Thiazoles / pharmacology
  • Viral Nonstructural Proteins / antagonists & inhibitors*
  • Viral Proteins / antagonists & inhibitors*

Substances

  • Antiviral Agents
  • BILN 2061
  • Carbamates
  • Carrier Proteins
  • Intracellular Signaling Peptides and Proteins
  • Macrocyclic Compounds
  • NS3 protein, hepatitis C virus
  • NS4A cofactor peptide, Hepatitis C virus
  • Protease Inhibitors
  • Quinolines
  • Thiazoles
  • Viral Nonstructural Proteins
  • Viral Proteins