Abstract
Positive and negative feedback loops are common regulatory elements in biological signaling systems. We discuss core feedback motifs that have distinct roles in shaping signaling responses in space and time. We also discuss approaches to experimentally investigate feedback loops in signaling systems.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Calcium / metabolism
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Calcium Signaling*
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Cell Membrane / metabolism
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Chemotaxis, Leukocyte
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Computer Simulation
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Endoplasmic Reticulum / metabolism
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Feedback, Physiological*
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Models, Biological
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Neutrophils / metabolism*
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Neutrophils / physiology
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Phosphatidylinositol 3-Kinases / metabolism*
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Signal Transduction*
Substances
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Phosphatidylinositol 3-Kinases
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Calcium