Abstract
This study investigated the effects of placebo, 1 mg, 3 mg, 10 mg and 30 mg ritanserin and 10 mg diazepam on human sleep. Twelve normal volunteers participated in this randomized, double-blind, placebo-controlled cross-over sleep study. A clear dose-response relationship was found for ritanserin with higher doses evoking increased duration of slow wave sleep.
Publication types
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Clinical Trial
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Randomized Controlled Trial
MeSH terms
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Adolescent
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Adult
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Diazepam / pharmacology
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Dose-Response Relationship, Drug
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Double-Blind Method
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Electroencephalography
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Electromyography
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Female
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Humans
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Male
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Piperidines / pharmacology*
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Ritanserin
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Sleep Stages / drug effects*
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Sleep, REM / drug effects
Substances
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Piperidines
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Ritanserin
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Diazepam