Drug-induced liver injury: hepatotoxicity of quetiapine revisited

Eur J Gastroenterol Hepatol. 2008 Nov;20(11):1106-9. doi: 10.1097/MEG.0b013e3282f8e3a0.

Abstract

Drug hepatotoxicity is the most common cause of fulminant hepatic failure in the USA. We describe a rare case of a patient who developed an acute liver injury after initiation of therapy with quetiapine, but after conservative management and a trial of steroids, has fully recovered. This is the second reported case of quetiapine-induced liver injury in the published literature.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Antipsychotic Agents / adverse effects*
  • Chemical and Drug Induced Liver Injury / etiology*
  • Chemical and Drug Induced Liver Injury / pathology
  • Cholestasis, Intrahepatic / chemically induced
  • Cholestasis, Intrahepatic / pathology
  • Dibenzothiazepines / adverse effects*
  • Humans
  • Male
  • Quetiapine Fumarate
  • Young Adult

Substances

  • Antipsychotic Agents
  • Dibenzothiazepines
  • Quetiapine Fumarate