Pestalofones A-E, bioactive cyclohexanone derivatives from the plant endophytic fungus Pestalotiopsis fici

Ling Liu; Shuchun Liu; Xulin Chen; Liangdong Guo; Yongsheng Che

doi:10.1016/j.bmc.2008.11.066

Pestalofones A-E, bioactive cyclohexanone derivatives from the plant endophytic fungus Pestalotiopsis fici

Bioorg Med Chem. 2009 Jan 15;17(2):606-13. doi: 10.1016/j.bmc.2008.11.066. Epub 2008 Dec 3.

Authors

Ling Liu¹, Shuchun Liu, Xulin Chen, Liangdong Guo, Yongsheng Che

Affiliation

¹ Key Laboratory of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, No. 13 Beiyitiao, Zhongguancun, Beijing 100080, People's Republic of China.

PMID: 19101157
DOI: 10.1016/j.bmc.2008.11.066

Abstract

Pestalofones A-E (1-5), five new cyclohexanone derivatives, have been isolated from cultures of the plant endophytic fungus Pestalotiopsis fici, along with the known compounds, isosulochrin (6), isosulochrin dehydrate (7), and iso-A82775C (8). The structures of 1-5 were determined by NMR spectroscopy, and the absolute configuration of 1 was assigned using the modified Mosher method. Compounds 1, 2, and 5 displayed inhibitory effects on HIV-1 replication in C8166 cells, whereas 3 and 5 showed significant antifungal activity against Aspergillus fumigatus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Infective Agents / chemistry*
Anti-Infective Agents / isolation & purification
Anti-Infective Agents / pharmacology
Aspergillus fumigatus / drug effects
Benzophenones
Cell Line
Cyclohexanones / chemistry*
Cyclohexanones / isolation & purification
Cyclohexanones / pharmacology*
Fungi / chemistry*
HIV-1 / drug effects
Humans
Magnetic Resonance Spectroscopy
Molecular Structure
Plants / microbiology
Virus Replication / drug effects

Substances

Anti-Infective Agents
Benzophenones
Cyclohexanones
pestalone
cyclohexanone