Review of methods for functional brain connectivity detection using fMRI

Comput Med Imaging Graph. 2009 Mar;33(2):131-9. doi: 10.1016/j.compmedimag.2008.10.011. Epub 2008 Dec 25.

Abstract

Since the mid of 1990s, functional connectivity study using fMRI (fcMRI) has drawn increasing attention of neuroscientists and computer scientists, since it opens a new window to explore functional network of human brain with relatively high resolution. A variety of methods for fcMRI study have been proposed. This paper intends to provide a technical review on computational methodologies developed for fcMRI analysis. From our perspective, these computational methods are classified into two general categories: model-driven methods and data-driven methods. Data-driven methods are a large family, and thus are further sub-classified into decomposition-based methods and clustering analysis methods. For each type of methods, principles, main contributors, and their advantages and drawbacks are discussed. Finally, potential applications of fcMRI are overviewed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Artificial Intelligence
  • Brain / physiology*
  • Brain / physiopathology*
  • Cluster Analysis
  • Humans
  • Image Processing, Computer-Assisted / methods*
  • Magnetic Resonance Imaging / methods*
  • Models, Neurological
  • Nerve Net / physiology
  • Nerve Net / physiopathology
  • Principal Component Analysis