Abstract
The elucidation of the crucial differentiation factors for the new Th17 CD4 effector T-cell subset spurred an explosive growth in research publications focused on these cells and led to rapid advances in knowledge concerning their regulation and functional activities. Here we discuss recent discoveries linking the development and functional potential of Th17 cells to a transcription factor that mediates the response to exogenous and endogenous environmental signals.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Aryl Hydrocarbon Hydroxylases / immunology*
-
Aryl Hydrocarbon Hydroxylases / metabolism
-
Humans
-
Interleukin-17 / immunology*
-
Interleukin-17 / metabolism
-
Interleukin-22
-
Interleukin-23 / immunology
-
Interleukin-23 / metabolism
-
Interleukins / immunology*
-
Interleukins / metabolism
-
Ligands
-
Receptors, Aryl Hydrocarbon / immunology*
-
Receptors, Aryl Hydrocarbon / metabolism
-
T-Lymphocyte Subsets / immunology
-
T-Lymphocyte Subsets / metabolism
-
T-Lymphocytes, Helper-Inducer / immunology*
-
T-Lymphocytes, Helper-Inducer / metabolism
Substances
-
Interleukin-17
-
Interleukin-23
-
Interleukins
-
Ligands
-
Receptors, Aryl Hydrocarbon
-
Aryl Hydrocarbon Hydroxylases