Alkenyl substituted bicyclic nucleoside analogues retain nanomolar potency against Varicella Zoster Virus

Christopher McGuigan; Olivier Bidet; Marco Derudas; Graciela Andrei; Robert Snoeck; Jan Balzarini

doi:10.1016/j.bmc.2009.03.022

Alkenyl substituted bicyclic nucleoside analogues retain nanomolar potency against Varicella Zoster Virus

Bioorg Med Chem. 2009 Apr 15;17(8):3025-7. doi: 10.1016/j.bmc.2009.03.022. Epub 2009 Mar 14.

Authors

Christopher McGuigan¹, Olivier Bidet, Marco Derudas, Graciela Andrei, Robert Snoeck, Jan Balzarini

Affiliation

¹ Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3NB, UK. mcguigan@cardiff.ac.uk

PMID: 19328697
DOI: 10.1016/j.bmc.2009.03.022

Abstract

Novel alkenyl substituted aryl bicyclic furano pyrimidines have been prepared and evaluated in vitro against Varicella Zoster Virus (VZV). The para-substituted analogues retain the nanomolar potency we have reported for p-alkyl analogues, while the ortho- and meta-alkenyl systems lose 3-4 orders of potency.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents / chemical synthesis
Antiviral Agents / chemistry*
Antiviral Agents / pharmacology*
Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis
Bridged Bicyclo Compounds, Heterocyclic / chemistry
Bridged Bicyclo Compounds, Heterocyclic / pharmacology
Herpesvirus 3, Human / drug effects*
Humans
Models, Molecular
Molecular Conformation
Nucleosides / chemical synthesis
Nucleosides / chemistry*
Nucleosides / pharmacology*
Structure-Activity Relationship

Substances

Antiviral Agents
Bridged Bicyclo Compounds, Heterocyclic
Nucleosides