Association of angiitis of central nervous system, cerebral amyloid angiopathy, and Alzheimer's disease: report of an autopsy case

Vasc Health Risk Manag. 2008;4(6):1471-4. doi: 10.2147/vhrm.s3818.

Abstract

The association of angiitis of central nervous system (ACNS) with cerebral amyloid angiopathy (CAA) suggests a physiopathological relationship between these two affections. Few cases are reported in patients with Alzheimer's disease (AD). We describe here a clinicopathological case associating ACNS, CAA, and AD. We discuss the aetiology of ACNS and its relationship with cerebral deposition of beta A4 amyloid protein (betaA4).

Keywords: Alzheimer’s disease; cerebral angiopathy.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Alzheimer Disease / metabolism
  • Alzheimer Disease / pathology*
  • Alzheimer Disease / therapy
  • Amyloid beta-Peptides / analysis
  • Autopsy
  • Brain / pathology*
  • Brain Chemistry
  • Cerebral Amyloid Angiopathy / metabolism
  • Cerebral Amyloid Angiopathy / pathology*
  • Cerebral Amyloid Angiopathy / therapy
  • Fatal Outcome
  • Female
  • Humans
  • Treatment Outcome
  • Vasculitis, Central Nervous System / metabolism
  • Vasculitis, Central Nervous System / pathology*
  • Vasculitis, Central Nervous System / therapy

Substances

  • Amyloid beta-Peptides