One flew over the progenitor's nest: migratory cells find a home in osteoarthritic cartilage

Cell Stem Cell. 2009 Apr 3;4(4):282-4. doi: 10.1016/j.stem.2009.03.007.

Abstract

Articular cartilage is the target tissue of osteoarthritis (OA), a degenerative disease with no cure. In this issue of Cell Stem Cell, Miosge and colleagues (Koelling et al., 2009) report that migratory progenitor cells occupy degenerating OA tissue but that this population is not present in healthy cartilage.

Publication types

  • Comment

MeSH terms

  • Cartilage, Articular / cytology
  • Cartilage, Articular / pathology*
  • Cell Movement*
  • Chondrocytes / metabolism
  • Chondrocytes / physiology*
  • Chondrogenesis / physiology
  • Collagen Type II / metabolism
  • Core Binding Factor Alpha 1 Subunit / genetics
  • Core Binding Factor Alpha 1 Subunit / metabolism
  • Humans
  • Osteoarthritis / pathology*
  • SOX9 Transcription Factor / metabolism
  • Stem Cells / metabolism
  • Stem Cells / physiology*

Substances

  • Collagen Type II
  • Core Binding Factor Alpha 1 Subunit
  • RUNX2 protein, human
  • SOX9 Transcription Factor
  • SOX9 protein, human