Complement and natural antibody are required in the long-term memory response to influenza virus

Santiago Fernandez Gonzalez; Jerome Priyantha Jayasekera; Michael C Carroll

doi:10.1016/j.vaccine.2008.11.057

Complement and natural antibody are required in the long-term memory response to influenza virus

Vaccine. 2008 Dec 30:26 Suppl 8:I86-93. doi: 10.1016/j.vaccine.2008.11.057.

Authors

Santiago Fernandez Gonzalez¹, Jerome Priyantha Jayasekera, Michael C Carroll

Affiliation

¹ Immune Disease Institute and Department of Pediatrics and Pathology, Harvard Medical School, 800 Huntington Avenue, Boston, MA 02115, USA.

PMID: 19388171
DOI: 10.1016/j.vaccine.2008.11.057

Abstract

Complement, complement receptors and natural antibody (IgM) are important factors in the immune response against pathogens. Previous studies have indicated a role for C3, the complement receptors CD35/CD21 (CR1/CR2), and IgM in the immune response to influenza virus. Nevertheless, their contribution to the long-term memory response to this pathogen remains unknown. To elucidate this role, we characterized the secondary response on mice deficient of CR1/CR2 (Cr2-/-), C3 (C3-/-), secreted IgM (micros-/-) and the double knockout C3-/-micros-/-. Overall, our results suggest that C3, IgM and CR1/CR2 play crucial roles in the maintenance of long-term memory to influenza virus, possibly through the development of memory B cells and long-term antibody secretion.

MeSH terms

Animals
Antibodies, Viral / blood
Complement C3 / physiology*
Immunoglobulin G / blood
Immunoglobulin M / physiology*
Immunologic Memory*
Mice
Mice, Inbred C57BL
Orthomyxoviridae / immunology*
Receptors, Complement 3b / physiology*
Receptors, Complement 3d / physiology*

Substances

Antibodies, Viral
Complement C3
Immunoglobulin G
Immunoglobulin M
Receptors, Complement 3b
Receptors, Complement 3d