Allogeneic mesenchymal stem cells transplantation in treatment of multiple sclerosis

J Liang; H Zhang; B Hua; H Wang; J Wang; Z Han; L Sun

doi:10.1177/1352458509104590

Allogeneic mesenchymal stem cells transplantation in treatment of multiple sclerosis

Mult Scler. 2009 May;15(5):644-6. doi: 10.1177/1352458509104590.

Authors

J Liang¹, H Zhang, B Hua, H Wang, J Wang, Z Han, L Sun

Affiliation

¹ Department of Immunology and Rheumatology, Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, P. R. China.

PMID: 19389752
DOI: 10.1177/1352458509104590

Abstract

Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system. Umbilical cord derived mesenchymal stem cells are immunosuppressive. We transplanted mesenchymal stem cells in a patient with refractory progressive MS, and the disease course was stabilized after the transplantation. We postulate that mesenchymal stem cells have a potent immunosuppressive effect in vivo.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Female
Humans
Immunosuppression Therapy*
Magnetic Resonance Imaging
Mesenchymal Stem Cell Transplantation*
Middle Aged
Multiple Sclerosis, Chronic Progressive / immunology*
Multiple Sclerosis, Chronic Progressive / pathology
Multiple Sclerosis, Chronic Progressive / therapy*
Spinal Cord / pathology
Transplantation, Homologous