Specifying mouse embryonic germ cells

Patrick P L Tam; David A F Loebel

doi:10.1016/j.cell.2009.04.016

Specifying mouse embryonic germ cells

Cell. 2009 May 1;137(3):398-400. doi: 10.1016/j.cell.2009.04.016.

Authors

Patrick P L Tam¹, David A F Loebel

Affiliation

¹ Children's Medical Research Institute, University of Sydney, Wentworthville, NSW, Australia. ptam@cmri.usyd.edu.au

PMID: 19410535
DOI: 10.1016/j.cell.2009.04.016

Abstract

Male germ cells are induced to form from the epiblast of the mouse embryo by a combination of WNT and bone morphogenetic protein signals. Ohinata et al. (2009) now clarify the steps of mouse germ cell formation and use this genetic insight to direct the specification and differentiation of germline progenitor cells in vitro.

Publication types

Comment

MeSH terms

Animals
Bone Morphogenetic Proteins / physiology
Cell Differentiation / physiology*
Cell Lineage / physiology
Embryo, Mammalian / cytology
Embryo, Mammalian / embryology
Embryo, Mammalian / physiology
Germ Cells / cytology*
Germ Cells / physiology
Male
Mesoderm / cytology*
Mesoderm / physiology
Mice
Signal Transduction / physiology
Stem Cells / cytology*
Stem Cells / physiology
Wnt Proteins / physiology

Substances

Bone Morphogenetic Proteins
Wnt Proteins