Abstract
trans- and cis-Icosyl, docosyl, and tetracosyl p-coumarates, constituents of Artemisia annua L., and their structurally-related compounds were synthesized and evaluated for inhibitory activity on DNA polymerases alpha and beta. Among 30 compounds synthesized, octadecyl trans- and cis-p-coumarates and octadecyl p-hydroxyphenylpropiolate showed strong inhibitory activity on DNA polymerases alpha and beta.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Coumaric Acids / chemical synthesis*
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Coumaric Acids / chemistry
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Coumaric Acids / pharmacology*
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DNA Polymerase I / antagonists & inhibitors
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DNA Polymerase I / chemistry*
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DNA Polymerase beta / antagonists & inhibitors
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DNA Polymerase beta / chemistry*
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Enzyme Inhibitors / pharmacology*
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Esters / chemical synthesis
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Esters / chemistry*
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Esters / pharmacology
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Humans
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Inhibitory Concentration 50
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Molecular Structure
Substances
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Coumaric Acids
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Enzyme Inhibitors
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Esters
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DNA Polymerase I
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DNA Polymerase beta