Fluorescent organic nanoparticle formation in lysosomes for cancer cell recognition

Org Biomol Chem. 2009 May 21;7(10):2036-9. doi: 10.1039/b902399b. Epub 2009 Apr 7.

Abstract

We present a convenient method to prepare fluorophores 3- or 3,7-divinyl substituted 10H-phenothiazines and their protonation forms can aggregate to become fluorescent organic nanoparticles (FONs) with bright fluorescent spots in the lysosomes of cancer cells but not normal cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Fluorescent Dyes / metabolism*
  • Humans
  • Lysosomes / chemistry
  • Lysosomes / metabolism*
  • Microscopy, Fluorescence
  • Nanoparticles / chemistry*
  • Nanostructures
  • Neoplasms / diagnosis
  • Neoplasms / pathology*
  • Phenothiazines / chemical synthesis*
  • Protons

Substances

  • Fluorescent Dyes
  • Phenothiazines
  • Protons