Tripping the HCN breaker

Neuron. 2009 Jun 25;62(6):747-50. doi: 10.1016/j.neuron.2009.06.003.

Abstract

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels regulate neuronal excitability, pacemaking, dendritic integration, and homeostatic plasticity and are culprits in aberrant neuronal activity in certain epilepsies. In this issue of Neuron two manuscripts (Santoro et al. and Zolles et al.) report that HCN channel gating and expression are controlled by Trip8b (Pex5R) but with a bidirectional spin.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cyclic Nucleotide-Gated Cation Channels / genetics
  • Cyclic Nucleotide-Gated Cation Channels / metabolism*
  • Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
  • Ion Channel Gating / physiology
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Peroxins
  • Potassium Channels / genetics
  • Potassium Channels / metabolism*

Substances

  • Cyclic Nucleotide-Gated Cation Channels
  • Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
  • Membrane Proteins
  • Peroxins
  • Pex5l protein, mouse
  • Potassium Channels