Abstract
Genetically engineered mouse models are powerful systems for dissecting the process of human leukemogenesis. In this issue of Cell Stem Cell, Schindler et al. (2009) describe the elegant use of this approach to dissect, but not completely replicate, the multistep pathogenesis of TEL-AML1(+) leukemia.
MeSH terms
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Animals
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Animals, Genetically Modified
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Core Binding Factor Alpha 2 Subunit / genetics*
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Core Binding Factor Alpha 2 Subunit / metabolism
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Disease Progression
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Leukemia, Myeloid, Acute / genetics*
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Mice
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Models, Animal
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Oncogene Fusion
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Oncogene Proteins, Fusion / genetics*
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Oncogene Proteins, Fusion / metabolism
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Oncogenes
Substances
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Core Binding Factor Alpha 2 Subunit
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Oncogene Proteins, Fusion
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TEL-AML1 fusion protein