HI: haplotype improver using paired-end short reads

Bioinformatics. 2009 Sep 15;25(18):2436-7. doi: 10.1093/bioinformatics/btp412. Epub 2009 Jul 1.

Abstract

Summary: We present a program to improve haplotype reconstruction by incorporating information from paired-end reads, and demonstrate its utility on simulated data. We find that given a fixed coverage, longer reads (implying fewer of them) are preferable.

Availability: The executable and user manual can be freely downloaded from ftp://ftp.sanger.ac.uk/pub/zn1/HI.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Computational Biology / methods*
  • Databases, Genetic
  • Haplotypes*
  • Molecular Sequence Data
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Software*