Ultra high-speed swept source OCT imaging of the anterior segment of human eye at 200 kHz with adjustable imaging range

Opt Express. 2009 Aug 17;17(17):14880-94. doi: 10.1364/oe.17.014880.

Abstract

We present an application of in vivo anterior segment imaging of the human eye with an ultrahigh speed swept source OCT instrument. For this purpose, a dedicated OCT system was designed and constructed. This instrument enables axial zooming by automatic reconfiguration of spectral sweep range; an enhanced imaging range mode enables imaging of the entire anterior segment while a high axial resolution mode provides detailed morphological information of the chamber angle and the cornea. The speed of 200,000 lines/s enables high sampling density in three-dimensional imaging of the entire cornea in 250 ms promising future applications of OCT for optical corneal topography, pachymetry and elevation maps. The results of a preliminary quantitative corneal analysis based on OCT data free form motion artifacts are presented. Additionally, a volumetric and real time reconstruction of dynamic processes, like pupillary reaction to light stimulus or blink-induced contact lens movements are demonstrated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Artifacts
  • Cornea / anatomy & histology
  • Corneal Topography / methods
  • Diagnostic Imaging / instrumentation*
  • Diagnostic Imaging / methods
  • Equipment Design
  • Eye / anatomy & histology*
  • Eye / pathology
  • Eye Diseases / diagnosis*
  • Eye Diseases / pathology
  • Fourier Analysis
  • Humans
  • Imaging, Three-Dimensional
  • Lasers
  • Motion
  • Ophthalmology / methods
  • Tomography, Optical Coherence / instrumentation*
  • Tomography, Optical Coherence / methods