Abstract
Drosophila has recently become a powerful model organism for studies of innate immunity. The cellular elements of innate immunity in Drosophila, the hemocytes, have been characterized by morphological criteria, molecular markers, and cell-type-specific immunological markers. Here we suggest that an MiET1 GFP-reporter element insertion in the untranslated region of a gene (l1-atilla) - expressed in a subset of hemocytes, the lamellocytes - allows in vivo investigations of lamellocyte differentiation and facilitates genetic screens.
Publication types
-
Letter
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Cell Differentiation
-
DNA Transposable Elements / genetics
-
Drosophila Proteins / genetics*
-
Drosophila melanogaster / genetics*
-
Drosophila melanogaster / metabolism
-
Fluorescent Antibody Technique, Indirect
-
Green Fluorescent Proteins / genetics
-
Green Fluorescent Proteins / metabolism
-
Hemocytes / cytology
-
Hemocytes / metabolism*
-
Larva / genetics
-
Larva / metabolism
-
Mutagenesis, Insertional
Substances
-
DNA Transposable Elements
-
Drosophila Proteins
-
Green Fluorescent Proteins