Abstract
Two members of the widely conserved HtrA family of serine proteases, DegP and DegS, are key players in extracytoplasmic protein quality control. The underlying mechanisms of their main functions in stress sensing, regulation and protection during the unfolded protein response are discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Escherichia coli / enzymology*
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Escherichia coli / genetics
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Escherichia coli Proteins / chemistry*
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Escherichia coli Proteins / metabolism*
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Gene Expression Regulation, Bacterial
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Heat-Shock Proteins / chemistry*
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Heat-Shock Proteins / metabolism*
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Periplasmic Proteins / chemistry*
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Periplasmic Proteins / metabolism*
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Serine Endopeptidases / chemistry*
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Serine Endopeptidases / metabolism*
Substances
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Escherichia coli Proteins
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Heat-Shock Proteins
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Periplasmic Proteins
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degS protein, Escherichia coli
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DegP protease
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Serine Endopeptidases