Abstract
We report the case of a patient with Parkinson's disease who developed rapidly progressive weakness of the four limbs due to an acute motor axonal neuropathy (AMAN). This occurred days after a neuroleptic malignant syndrome (NMS). Serologic evidence of a preceding Campylobacter jejuni infection was detected and treatment with intravenous immunoglobulins proved effective. This case suggests that the rarely described neuropathies occurring with NMS may have a postinfectious immune basis and respond to immunomodulatory therapy.
MeSH terms
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Antibodies, Bacterial / blood
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Antibodies, Bacterial / immunology
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Antiparkinson Agents / adverse effects
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Antiparkinson Agents / therapeutic use
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Campylobacter Infections / complications*
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Campylobacter Infections / diagnosis
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Campylobacter jejuni*
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Electromyography
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Fever / etiology
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G(M1) Ganglioside / immunology
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Guillain-Barre Syndrome / etiology*
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Guillain-Barre Syndrome / therapy
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Humans
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Immunoglobulin G / blood
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Immunoglobulin G / immunology
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Immunoglobulin M / blood
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Immunoglobulin M / immunology
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Immunoglobulins, Intravenous / therapeutic use
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Lipopolysaccharides / immunology
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Male
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Middle Aged
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Molecular Mimicry
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Neural Conduction
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Neuroleptic Malignant Syndrome / etiology*
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Parkinson Disease / complications*
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Parkinson Disease / drug therapy
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Quadriplegia / etiology*
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Unconsciousness / etiology
Substances
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Antibodies, Bacterial
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Antiparkinson Agents
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Immunoglobulin G
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Immunoglobulin M
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Immunoglobulins, Intravenous
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Lipopolysaccharides
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G(M1) Ganglioside