High-speed microwave-assisted synthesis of the trifluoromethylpyrazol-derived canonical transient receptor potential (TRPC) channel inhibitor Pyr3

ChemMedChem. 2009 Nov;4(11):1816-8. doi: 10.1002/cmdc.200900304.

Authors

Toma N Glasnov¹, Klaus Groschner, C Oliver Kappe

Affiliation

¹ Institute of Chemistry, Karl-Franzens-University Graz, Austria.

PMID: 19728347
DOI: 10.1002/cmdc.200900304

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acrylamides / chemical synthesis*
Acrylamides / chemistry
Acrylamides / pharmacology
Microwaves*
NFATC Transcription Factors / metabolism
Pyrazoles / chemical synthesis
Pyrazoles / chemistry*
Pyrazoles / pharmacology
TRPC Cation Channels / antagonists & inhibitors*
TRPC Cation Channels / metabolism

Substances

Acrylamides
NFATC Transcription Factors
Pyrazoles
TRPC Cation Channels
ethyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate