Growth factors and corneal epithelial wound healing

Fu-Shin X Yu; Jia Yin; Keping Xu; Jenny Huang

doi:10.1016/j.brainresbull.2009.08.024

Growth factors and corneal epithelial wound healing

Brain Res Bull. 2010 Feb 15;81(2-3):229-35. doi: 10.1016/j.brainresbull.2009.08.024. Epub 2009 Sep 4.

Authors

Fu-Shin X Yu¹, Jia Yin, Keping Xu, Jenny Huang

Affiliation

¹ Kresge Eye Institute, Departments of Ophthalmology and Anatomy and Cell Biology, Wayne State University School of Medicine, 4717 St. Antoine Blvd., Detroit, MI, 48201, USA. fyu@med.wayne.edu

Abstract

In this article, we briefly review recent findings in the effects of growth factors including the EGF family, KGF, HGF, IGF, insulin, and TGF-beta on corneal epithelial wound healing. We discuss the essential role of EGFR in inter-receptor cross-talk in response to wounding in corneal epithelium and bring forward a concept of "alarmins" to the field of wound healing research.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Corneal Diseases* / pathology
Corneal Diseases* / physiopathology
Corneal Diseases* / therapy
Epithelium, Corneal / physiopathology*
Humans
Intercellular Signaling Peptides and Proteins / classification
Intercellular Signaling Peptides and Proteins / physiology*
Models, Biological
Signal Transduction / physiology
Wound Healing / physiology*

Substances

Intercellular Signaling Peptides and Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding