Abstract
Nep1 from Methanocaldococcus jannaschii is a 48 kDa dimeric protein belonging to the SPOUT-class of S-adenosylmethionine dependent RNA-methyltransferases and acting as a ribosome assembly factor. Mutations in the human homolog are the cause of Bowen-Conradi syndrome. We report here 1H, 15N and 13C chemical shift assignments for the backbone of the protein in its apo state.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Methanococcales / enzymology*
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Methyltransferases / chemistry*
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Methyltransferases / metabolism*
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Models, Molecular
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Molecular Weight
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Nuclear Magnetic Resonance, Biomolecular
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Protein Multimerization*
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Protein Structure, Quaternary
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RNA, Ribosomal, 18S / metabolism*
Substances
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RNA, Ribosomal, 18S
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Methyltransferases