Several million individuals with cleft lip and palate (CLP) exist in China, and it is estimated that at least 30,000 newborns with CLP are born every year. How to give them an optimal treatment with excellence is still a problem in most areas. The treatment of cleft patients presents various situations around world that are different from those in the United States and Europe. In this article, we reviewed the current status of CLP management in our country and shared our experience from one of the biggest CLP centers in China. We hope the management of cleft can be improved, and more patients can be treated by dedicated teams and dedicated centers in China.