Abstract
Colonic sensorimotor dysfunction is recognized as the principal pathophysiological mechanism underpinning chronic constipation. This review addresses current understanding derived from both human and animal studies, with particular reference made to methods of investigation.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Chronic Disease
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Circadian Rhythm / physiology
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Colon / diagnostic imaging
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Colon / physiopathology*
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Constipation / diagnostic imaging
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Constipation / physiopathology*
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Disease Models, Animal
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Gastrointestinal Motility / physiology
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Gastrointestinal Transit / physiology
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Humans
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Manometry
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Pressure
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Radiography
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Radionuclide Imaging
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Reflex / physiology