Cytotoxic effect of flavonoids on leukemia cells and normal cells of human blood

T V Romanouskaya; V V Grinev

doi:10.1007/s10517-009-0633-9

Cytotoxic effect of flavonoids on leukemia cells and normal cells of human blood

Bull Exp Biol Med. 2009 Jul;148(1):57-9. doi: 10.1007/s10517-009-0633-9.

Authors

T V Romanouskaya¹, V V Grinev

Affiliation

¹ Belarussian State University, Minsk, Belarussia. romanovskaya.t@mail.ru

PMID: 19902097
DOI: 10.1007/s10517-009-0633-9

Abstract

We compared the cytotoxic effect of 11 flavonoids on chronic myeloid leukemia (erythroblast crisis) K562 cells and peripheral blood mononuclear cells from healthy donors. Baicalein and myricetin had a specific cytotoxic effect on leukemia cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / pharmacology*
Cell Survival / drug effects
Drug Screening Assays, Antitumor
Flavonoids / pharmacology*
Humans
K562 Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology*

Substances

Antineoplastic Agents
Flavonoids