Biological screening of a diverse set of AI-2 analogues in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous

Jacqueline A I Smith; Jingxin Wang; Sao-Mai Nguyen-Mau; Vincent Lee; Herman O Sintim

doi:10.1039/b909666c

Biological screening of a diverse set of AI-2 analogues in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous

Chem Commun (Camb). 2009 Dec 7:(45):7033-5. doi: 10.1039/b909666c. Epub 2009 Oct 13.

Authors

Jacqueline A I Smith¹, Jingxin Wang, Sao-Mai Nguyen-Mau, Vincent Lee, Herman O Sintim

Affiliation

¹ Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.

PMID: 19904385
DOI: 10.1039/b909666c

Abstract

C1-alkyl AI-2 analogues do not induce bioluminescence in V. harveyi on their own but enhance the bioluminescence induced by AI-2 in a synergistic fashion. A new facile synthesis of AI-2 facilitates the synthesis of a diverse set of AI-2 analogues and biological screening suggests that receptors that are involved in the synergistic bioluminescence production in V. harveyi are promiscuous.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Bacterial Proteins / metabolism
Carbon-Sulfur Lyases / metabolism
Drug Agonism
Homoserine / analogs & derivatives*
Homoserine / chemical synthesis
Homoserine / chemistry
Lactones / chemical synthesis
Lactones / chemistry*
Luminescent Measurements
Vibrio / chemistry*

Substances

Bacterial Proteins
Lactones
N-octanoylhomoserine lactone
Homoserine
Carbon-Sulfur Lyases
LuxS protein, Bacteria