BAX and BAK caught in the act

Mol Cell. 2009 Nov 13;36(3):353-4. doi: 10.1016/j.molcel.2009.10.023.

Abstract

In this issue of Molecular Cell, Kim et al. (2009) describe the steps involved in the direct activation of the proapoptotic proteins BAX and BAK by their BH3-only partners, resolving the controversy regarding direct versus indirect activation of these proteins.

Publication types

  • Comment

MeSH terms

  • Animals
  • Apoptosis Regulatory Proteins / metabolism
  • Apoptosis*
  • BH3 Interacting Domain Death Agonist Protein / metabolism
  • Bcl-2-Like Protein 11
  • Cells, Cultured
  • Fibroblasts / cytology
  • Fibroblasts / metabolism
  • Membrane Proteins / metabolism
  • Mice
  • Mice, Knockout
  • Mitochondria / metabolism*
  • Models, Biological
  • Protein Binding
  • Protein Multimerization
  • Proto-Oncogene Proteins / metabolism
  • Tumor Suppressor Proteins / metabolism
  • bcl-2 Homologous Antagonist-Killer Protein / chemistry
  • bcl-2 Homologous Antagonist-Killer Protein / genetics
  • bcl-2 Homologous Antagonist-Killer Protein / metabolism*
  • bcl-2-Associated X Protein / chemistry
  • bcl-2-Associated X Protein / genetics
  • bcl-2-Associated X Protein / metabolism*

Substances

  • Apoptosis Regulatory Proteins
  • BH3 Interacting Domain Death Agonist Protein
  • Bak1 protein, mouse
  • Bax protein, mouse
  • Bcl-2-Like Protein 11
  • Bcl2l11 protein, mouse
  • Membrane Proteins
  • PUMA protein, mouse
  • Proto-Oncogene Proteins
  • Tumor Suppressor Proteins
  • bcl-2 Homologous Antagonist-Killer Protein
  • bcl-2-Associated X Protein