Abstract
Alpha-tocopherol was synthesized from a chiral intermediate alpha-hydroxy ester by means of two ring-closing methods to yield the chromanol in 94% diastereomeric excess.
MeSH terms
-
Chromans / chemistry
-
Cyclization
-
Stereoisomerism
-
alpha-Tocopherol / chemical synthesis*
-
alpha-Tocopherol / chemistry
Substances
-
Chromans
-
2,2,5,7,8-pentamethyl-1-hydroxychroman
-
alpha-Tocopherol