Abstract
The study was performed to determine whether there were any associations of VacA positive Helicobacter pylori and TGF-β1 with atrial fibrillation (AF). The serum levels of antibodies to H. pylori and VacA, and cytokines were assessed using ELISA in 96 subjects. While elevated levels of TNF-α, IL-6 and CRP were associated with AF, TGF-β(1) was significantly lowered in AF patients (p=0.021). In addition, AF was associated with elevated levels of antibodies to VacA (p=0.023), compared to the control group. Accordingly, the chronic infection of VacA(+)H. pylori may increase the risk for AF by inducing systemic inflammation mediated, partly by suppressed TGF-β(1) and elevated proinflammatory cytokines.
Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.
Publication types
-
Comparative Study
-
Letter
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Atrial Fibrillation / blood
-
Atrial Fibrillation / microbiology*
-
Atrial Fibrillation / pathology
-
Bacterial Proteins / biosynthesis
-
Bacterial Proteins / blood*
-
Biomarkers / blood
-
Chronic Disease
-
Cytotoxins / biosynthesis
-
Cytotoxins / blood*
-
Female
-
Helicobacter Infections / blood
-
Helicobacter Infections / microbiology
-
Helicobacter Infections / pathology
-
Helicobacter pylori* / isolation & purification
-
Humans
-
Inflammation / blood
-
Inflammation / microbiology
-
Inflammation / pathology
-
Male
-
Middle Aged
-
Time Factors
-
Transforming Growth Factor beta1 / antagonists & inhibitors*
-
Transforming Growth Factor beta1 / blood*
Substances
-
Bacterial Proteins
-
Biomarkers
-
Cytotoxins
-
Transforming Growth Factor beta1
-
VacA protein, Helicobacter pylori