Lipophilic pyridinium bisphosphonates: potent gammadelta T cell stimulators

Angew Chem Int Ed Engl. 2010 Feb 1;49(6):1136-8. doi: 10.1002/anie.200905933.

Authors

Yonghui Zhang¹, Rong Cao, Fenglin Yin, Fu-Yang Lin, Hong Wang, Kilannin Krysiak, Joo-Hwan No, Dushyant Mukkamala, Kevin Houlihan, Jikun Li, Craig T Morita, Eric Oldfield

Affiliation

¹ Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL 61801, USA.

No abstract available

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Alkyl and Aryl Transferases / antagonists & inhibitors
Alkyl and Aryl Transferases / chemistry
Alkyl and Aryl Transferases / metabolism
Amino Acid Sequence
Animals
Cell Line
Diphosphonates / chemistry*
Diphosphonates / immunology*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology
Humans
Hydrophobic and Hydrophilic Interactions*
Lymphocyte Activation
Molecular Sequence Data
Pyridinium Compounds / chemistry*
Pyridinium Compounds / immunology*
Receptors, Antigen, T-Cell, gamma-delta / immunology
Sequence Alignment
Structure-Activity Relationship
T-Lymphocytes / immunology*

Substances

Diphosphonates
Enzyme Inhibitors
Pyridinium Compounds
Receptors, Antigen, T-Cell, gamma-delta
Alkyl and Aryl Transferases
dehydrodolichyl diphosphate synthetase

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