Galactosylated cucurbituril-inclusion polyplex for hepatocyte-targeted gene delivery

Soo Kyung Kim; Kyeng Min Park; Kaushik Singha; Jeeyeon Kim; Youngjoo Ahn; Kimoon Kim; Won Jong Kim

doi:10.1039/b920753h

Galactosylated cucurbituril-inclusion polyplex for hepatocyte-targeted gene delivery

Chem Commun (Camb). 2010 Feb 7;46(5):692-4. doi: 10.1039/b920753h. Epub 2009 Dec 16.

Authors

Soo Kyung Kim¹, Kyeng Min Park, Kaushik Singha, Jeeyeon Kim, Youngjoo Ahn, Kimoon Kim, Won Jong Kim

Affiliation

¹ Department of Chemistry, BK21 Program, Polymer Research Institute, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Korea.

PMID: 20087489
DOI: 10.1039/b920753h

Abstract

The work demonstrates a judicious approach to achieve hepatocyte cell-targeted highly efficient gene delivery by utilizing a supramolecular complex of galactosylated cucurbituril and dextran-spermine conjugates.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Dextrans / chemistry
Dextrans / metabolism
Drug Delivery Systems*
Galactose / chemistry
Galactose / metabolism*
Genetic Therapy / methods*
Genetic Vectors / chemical synthesis
Genetic Vectors / chemistry
Genetic Vectors / metabolism*
Hepatocytes / chemistry
Hepatocytes / cytology
Hepatocytes / metabolism*
Humans
Macrocyclic Compounds / chemistry
Macrocyclic Compounds / metabolism*
Macromolecular Substances / chemical synthesis
Macromolecular Substances / chemistry
Macromolecular Substances / metabolism
Spermine / chemistry
Spermine / metabolism

Substances

Dextrans
Macrocyclic Compounds
Macromolecular Substances
cucurbit(n)uril
Spermine
Galactose