Abstract
The aqueous and organic extracts of Acacia visco Lor. Ap Griseb (Fabaceae) were tested for anti-inflammatory activity in experimental models in rat. Besides, the free-radical scavenging capacity of extracts from A. visco was determined. The extracts revealed anti-inflammatory effect against carrageenan-induced oedema, phospholipase A(2)-induced oedema, cotton pellet-induced granuloma and they did not show acute toxic effect. Among the class of compounds characterized from A. visco leaves, the triterpenoid 20(29)-lupen-3β-ol (lupeol), 12-ursen-3β-ol (α-amyrin) and 12-oleanen-3β-ol (β-amyrin) may be mainly responsible for the pharmacological activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acacia*
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Animals
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Anti-Inflammatory Agents / pharmacology*
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Anti-Inflammatory Agents / toxicity
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Carrageenan
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Edema / chemically induced
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Edema / pathology
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Edema / prevention & control*
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Female
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Granuloma / chemically induced
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Granuloma / prevention & control
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Male
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Mice
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Oleanolic Acid / analogs & derivatives*
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Oleanolic Acid / therapeutic use
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Pentacyclic Triterpenes / therapeutic use*
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Phospholipases A2
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Phytotherapy
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Plant Extracts / pharmacology
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Plant Extracts / toxicity
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Plant Leaves
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Rats
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Rats, Wistar
Substances
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Anti-Inflammatory Agents
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Pentacyclic Triterpenes
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Plant Extracts
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Oleanolic Acid
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Carrageenan
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Phospholipases A2
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beta-amyrin
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lupeol