Corneal chrysiasis: in vivo confocal microscopy analysis

Eur J Ophthalmol. 2010 Jul-Aug;20(4):776-9. doi: 10.1177/112067211002000421.

Abstract

Purpose: To describe the in vivo confocal microscopy corneal findings in a patient treated with gold sodium thiomalate.

Methods: A woman with rheumatoid arthritis who had been treated with gold sodium thiomalate for 32 years came to our center for an ophthalmologic examination about 5 years ago. Besides visual acuity, the examination included slit-lamp biomicroscopy, intraocular pressure, and funduscopy. Confocal microscopy was performed using Confoscan 4 (Nidek Technologies, Padova, Italy) with a 40x lens.

Results: Every layer of the cornea is affected by gold deposits with high reflectivity, especially in the anterior stroma, where they have a larger dimension.

Conclusions: Corneal chrysiasis can be evaluated by confocal microscopy, giving information on corneal metabolism and physiology.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antirheumatic Agents / adverse effects
  • Arthritis, Rheumatoid / drug therapy
  • Cornea / drug effects
  • Cornea / pathology*
  • Corneal Diseases / chemically induced
  • Corneal Diseases / pathology*
  • Diagnosis, Differential
  • Female
  • Gold Sodium Thiomalate / adverse effects*
  • Humans
  • Microscopy, Confocal / methods*
  • Reproducibility of Results

Substances

  • Antirheumatic Agents
  • Gold Sodium Thiomalate