Abstract
Investigated association of single nucleotide polymorphism (SNP) rs301430 in glutamate transporter gene (SLC1A1) with severity of repetitive behaviors (obsessive-compulsive behaviors, tics) and anxiety in children with autism spectrum disorder (ASD). Mothers and/or teachers completed a validated DSM-IV-referenced rating scale for 67 children with autism spectrum disorder. Although analyses were not significant for repetitive behaviors, youths homozygous for the high expressing C allele had more severe anxiety than carriers of the T allele. Allelic variation in SLC1A1 may be a biomarker for or modifier of anxiety symptom severity in children with ASD, but study findings are best conceptualized as tentative pending replication with larger independent samples.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Alleles
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Anxiety / complications
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Anxiety / genetics*
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Anxiety / psychology
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Child
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Child Development Disorders, Pervasive / complications
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Child Development Disorders, Pervasive / genetics*
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Child Development Disorders, Pervasive / psychology
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Child, Preschool
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Excitatory Amino Acid Transporter 3 / genetics*
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Female
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Genotype
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Humans
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Male
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Obsessive-Compulsive Disorder / complications
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Obsessive-Compulsive Disorder / genetics
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Obsessive-Compulsive Disorder / psychology
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Polymorphism, Single Nucleotide / genetics*
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Stereotypic Movement Disorder / complications
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Stereotypic Movement Disorder / genetics*
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Stereotypic Movement Disorder / psychology
Substances
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Excitatory Amino Acid Transporter 3
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SLC1A1 protein, human