Dietary polyphenols, inflammation, and cancer

Nutr Cancer. 2009;61(6):807-10. doi: 10.1080/01635580903285098.

Abstract

A considerable amount of evidence indicates that tumorigenesis is associated with inflammation. Nuclear factor-kappa B (NF-kappa B), a master regulator of infection and inflammation, has been identified as a key modulator in which inflammation could develop into cancer. Dietary polyphenols have been shown to have anti-inflammatory and anticancer activity partially through inhibition of NF-kappa B activation. This review summarizes the effect of polyphenols on inflammation and cancer; avenanthramides, a unique polyphenol from oats, are especially focused.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal* / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal* / pharmacology
  • Anticarcinogenic Agents* / administration & dosage
  • Anticarcinogenic Agents* / pharmacology
  • Antioxidants* / administration & dosage
  • Antioxidants* / pharmacology
  • Avena / chemistry
  • Cell Proliferation / drug effects
  • Diet*
  • Disease Progression
  • Flavonoids* / administration & dosage
  • Flavonoids* / pharmacology
  • Humans
  • Inflammation Mediators / antagonists & inhibitors
  • Inflammation Mediators / metabolism
  • Inflammation* / complications
  • Inflammation* / metabolism
  • Inflammation* / prevention & control
  • NF-kappa B / antagonists & inhibitors
  • NF-kappa B / metabolism
  • Neoplasms / prevention & control*
  • Oxidative Stress
  • Phenols* / administration & dosage
  • Phenols* / pharmacology
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology
  • Polyphenols
  • Seeds / chemistry

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Anticarcinogenic Agents
  • Antioxidants
  • Flavonoids
  • Inflammation Mediators
  • NF-kappa B
  • Phenols
  • Plant Extracts
  • Polyphenols