Abstract
A considerable amount of evidence indicates that tumorigenesis is associated with inflammation. Nuclear factor-kappa B (NF-kappa B), a master regulator of infection and inflammation, has been identified as a key modulator in which inflammation could develop into cancer. Dietary polyphenols have been shown to have anti-inflammatory and anticancer activity partially through inhibition of NF-kappa B activation. This review summarizes the effect of polyphenols on inflammation and cancer; avenanthramides, a unique polyphenol from oats, are especially focused.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal* / administration & dosage
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Anti-Inflammatory Agents, Non-Steroidal* / pharmacology
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Anticarcinogenic Agents* / administration & dosage
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Anticarcinogenic Agents* / pharmacology
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Antioxidants* / administration & dosage
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Antioxidants* / pharmacology
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Avena / chemistry
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Cell Proliferation / drug effects
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Diet*
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Disease Progression
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Flavonoids* / administration & dosage
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Flavonoids* / pharmacology
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Humans
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Inflammation Mediators / antagonists & inhibitors
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Inflammation Mediators / metabolism
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Inflammation* / complications
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Inflammation* / metabolism
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Inflammation* / prevention & control
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NF-kappa B / antagonists & inhibitors
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NF-kappa B / metabolism
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Neoplasms / prevention & control*
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Oxidative Stress
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Phenols* / administration & dosage
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Phenols* / pharmacology
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology
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Polyphenols
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Seeds / chemistry
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Anticarcinogenic Agents
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Antioxidants
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Flavonoids
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Inflammation Mediators
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NF-kappa B
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Phenols
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Plant Extracts
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Polyphenols