Abstract
The microbial transformation of simvastatin (MK-733) by Nocardia autotrophica subspecies amethystina yielded iso-simvastatin-6-one as a minor component. This transformation product is a dienone and is one of the more potent inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase found to date.
MeSH terms
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Animals
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Fermentation
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Hydroxylation
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Hydroxymethylglutaryl-CoA Reductase Inhibitors*
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Liver / enzymology
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Lovastatin / analogs & derivatives*
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Lovastatin / chemistry
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Lovastatin / isolation & purification
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Lovastatin / metabolism
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Lovastatin / pharmacology
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Structure
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Nocardia / metabolism*
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Rats
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Simvastatin
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
Substances
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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L 669262
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Lovastatin
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Simvastatin