L-669,262, a potent HMG-CoA reductase inhibitor

J Antibiot (Tokyo). 1991 Mar;44(3):366-70. doi: 10.7164/antibiotics.44.366.

Abstract

The microbial transformation of simvastatin (MK-733) by Nocardia autotrophica subspecies amethystina yielded iso-simvastatin-6-one as a minor component. This transformation product is a dienone and is one of the more potent inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase found to date.

MeSH terms

  • Animals
  • Fermentation
  • Hydroxylation
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors*
  • Liver / enzymology
  • Lovastatin / analogs & derivatives*
  • Lovastatin / chemistry
  • Lovastatin / isolation & purification
  • Lovastatin / metabolism
  • Lovastatin / pharmacology
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Structure
  • Nocardia / metabolism*
  • Rats
  • Simvastatin
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet

Substances

  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • L 669262
  • Lovastatin
  • Simvastatin