Abstract
The in vitro activities of ACH-702 and other antimicrobials against 30 Nocardia brasiliensis isolates were tested. The MIC(50) (MIC for 50% of the strains tested) and MIC(90) values of ACH-702 were 0.125 and 0.5 microg/ml. The same values for econazole were 2 and 4 microg/ml. The MIC(50) and MIC(90) values of imipenem and meropenem were 64 and >64 microg/ml and 2 and 8 microg/ml, respectively; the addition of clavulanic acid to the carbapenems had no effect.
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Clavulanic Acid / pharmacology*
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Drug Therapy, Combination
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Econazole / pharmacology*
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Humans
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Imipenem / pharmacology*
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In Vitro Techniques
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Meropenem
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Mycetoma / drug therapy
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Mycetoma / microbiology
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Nocardia / drug effects*
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Nocardia Infections / drug therapy
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Nocardia Infections / microbiology
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Quinolones / chemistry
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Quinolones / pharmacology*
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Thiazoles / chemistry
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Thiazoles / pharmacology*
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Thienamycins / pharmacology*
Substances
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ACH 702
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Anti-Bacterial Agents
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Quinolones
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Thiazoles
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Thienamycins
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Clavulanic Acid
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Econazole
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Imipenem
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Meropenem