Over the last decade, smoking with a narghile pipe has taken alarming proportions and is now considered to be a worldwide epidemic. However, most knowledge about the effects of narghile smoke on health is partial and sometimes contradictory. Indeed, we are witnessing a growing confusion in biomedical studies, including the relationship between the use of the narghile and certain diseases such as lung cancer and bacterial or parasitic infections. Given this situation, the authors carried out the second part of the study to point out the health consequences of the narghile with special attention to the cardiorespiratory disorders.