Inhibition of JAK-STAT signaling by TG101348: a novel mechanism for inhibition of KITD816V-dependent growth in mast cell leukemia cells

Leukemia. 2010 Jul;24(7):1378-80. doi: 10.1038/leu.2010.109. Epub 2010 May 20.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Proliferation / drug effects*
  • Cells, Cultured
  • Dasatinib
  • Drug Synergism
  • Humans
  • Janus Kinase 2 / antagonists & inhibitors*
  • Janus Kinase 2 / metabolism
  • Leukemia / drug therapy*
  • Leukemia / metabolism
  • Leukemia / pathology
  • Mast Cells / drug effects*
  • Mutation / genetics
  • Protein Kinase Inhibitors / pharmacology
  • Protein-Tyrosine Kinases / antagonists & inhibitors
  • Proto-Oncogene Proteins c-kit / genetics
  • Proto-Oncogene Proteins c-kit / metabolism*
  • Pyrimidines / pharmacology
  • Pyrrolidines / pharmacology*
  • STAT5 Transcription Factor / antagonists & inhibitors*
  • STAT5 Transcription Factor / metabolism
  • Signal Transduction / drug effects
  • Sulfonamides / pharmacology*
  • Thiazoles / pharmacology

Substances

  • Protein Kinase Inhibitors
  • Pyrimidines
  • Pyrrolidines
  • STAT5 Transcription Factor
  • Sulfonamides
  • Thiazoles
  • fedratinib
  • Protein-Tyrosine Kinases
  • Proto-Oncogene Proteins c-kit
  • JAK2 protein, human
  • Janus Kinase 2
  • Dasatinib